| 1,781 | Aug 23, 2009 | PSV Eindhoven beat NAC Breda 3–1 | Title change |
| 1,782 | Aug 30, 2009 | PSV Eindhoven beat FC Groningen 2–0 | Defense |
| 1,783 | Sep 12, 2009 | PSV Eindhoven beat Roda JC Kerkrade 3–0 | Defense |
| 1,784 | Sep 20, 2009 | PSV Eindhoven beat Feyenoord 3–1 | Defense |
| 1,785 | Sep 26, 2009 | PSV Eindhoven beat Willem II 3–1 | Defense |
| 1,786 | Oct 4, 2009 | PSV Eindhoven and FC Utrecht tied 0–0 | Tie · defense |
| 1,787 | Oct 17, 2009 | PSV Eindhoven beat sc Heerenveen 1–0 | Defense |
| 1,788 | Oct 25, 2009 | PSV Eindhoven beat NEC Nijmegen 4–0 | Defense |
| 1,789 | Oct 31, 2009 | PSV Eindhoven beat Vitesse 1–0 | Defense |
| 1,790 | Nov 8, 2009 | PSV Eindhoven beat ADO Den Haag 5–1 | Defense |
| 1,791 | Nov 22, 2009 | PSV Eindhoven beat Heracles Almelo 4–0 | Defense |
| 1,792 | Nov 27, 2009 | PSV Eindhoven beat Sparta Rotterdam 3–2 | Defense |
| 1,793 | Dec 6, 2009 | PSV Eindhoven beat RKC Waalwijk 2–0 | Defense |
| 1,794 | Dec 12, 2009 | PSV Eindhoven beat AZ Alkmaar 1–0 | Defense |
| 1,795 | Jan 19, 2010 | PSV Eindhoven beat Roda JC Kerkrade 1–0 | Defense |
| 1,796 | Jan 22, 2010 | PSV Eindhoven beat NEC Nijmegen 3–0 | Defense |
| 1,797 | Jan 31, 2010 | PSV Eindhoven and Vitesse tied 0–0 | Tie · defense |
| 1,798 | Feb 3, 2010 | PSV Eindhoven beat FC Utrecht 2–1 | Defense |
| 1,799 | Feb 6, 2010 | PSV Eindhoven beat ADO Den Haag 2–0 | Defense |
| 1,800 | Feb 14, 2010 | PSV Eindhoven beat Heracles Almelo 1–0 | Defense |
| 1,801 | Feb 21, 2010 | PSV Eindhoven and Sparta Rotterdam tied 1–1 | Tie · defense |
| 1,802 | Feb 28, 2010 | PSV Eindhoven beat RKC Waalwijk 5–1 | Defense |
| 1,803 | Mar 6, 2010 | NAC Breda beat PSV Eindhoven 2–1 | Title change |